Heparin Resistant Recalcifying Solution
Antihepca™-HRRS is a simple and quick recalcifying reagent that can identify & neutralise heparin contamination.
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recalcifying solution
IVD (ARTG listed)
Product Code:
12 x 5ml
5 x 10ml
5 x 10ml
5 years

Product Features:

Compatible with APTT on an analyzer
Streamlined process, easy to implement

Product Description:

Antihepca™-HRRS can be substituted for the usual M/40 calcium chloride solution in APTT and KCT tests to virtually eliminate the effect of unfractionated heparin concentrations up to 1 U/ml in normal plasma.​

Heparins are widely used in hospitals as anticoagulants. Unfractionated heparin is usually monitored using APTT and thrombin time tests. Often plasma samples are not identified as containing heparin and it may be present as an unexpected contaminant. Thus the reason for prolonged APTT or KCT tests may not be apparent and laboratory diagnosis may not be simple. Laboratories may find it useful to have a simple method for confirming the presence of heparin before going on to other investigations as may be required.

​Several methods are available to remove heparin including heparinase enzyme (expensive), adsorbing agents such as ECTEOLA cellulose (not so simple) and specially treated filters. Some polymers have also been widely used to neutralise heparin, however, in excess, they can interfere with contact activators used in most APTT reagents. Thus it is more reliable to add the heparin neutralising agent in the calcium chloride solution after the contact activation stage in APTTs or KCTs. Antihepca HRRS is a simple and unique product which we believe will play a regular role in routine coagulation testing.

We guarantee a competitive price for our reagents. ​

Instructions for Use:

IFU - ARTG Listed (Australia)IFU - Antihepca™-HRRS RUO (International)IFU - CE Marked (Europe)IFU - RUO (U.S.A.)
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2. Richard S. Newman, Awilda R. Fagin, “Heparin Contamination in Coagulation Testing and a Protocol to Avoid It and the Risk of Inappropriate FFP Transfusion”, American Journal of Clinical Pathology, Volume 104, Issue 4, 1 October 1995, Pages 447-449.

3. J.M. Brown, G. Dimeski. “Contamination of coagulation tests with heparin from blood gas samples” British Journal of Anaesthesia, Volume 87, Issue 4, 2001, Pages 628-629.

4. Santoro, Rita Carlotta, Angelo Claudio Molinari, Marzia Leotta, and Tiziano Martini. 2023. "Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!" Medicina 59, no. 6: 1169.

5. Frackiewicz, A., Kalaska, B., Miklosz, J. et al. “The methods for removal of direct oral anticoagulants and heparins to improve the monitoring of hemostasis: a narrative literature review”. Thrombosis J 21, 58 (2023).

6. Tientadakul, Panutsaya et al. “Use of an automated coagulation analyzer to perform heparin neutralization with polybrene in blood samples for routine coagulation testing: practical, rapid, and inexpensive.” Archives of pathology & laboratory medicine vol. 137,11 (2013): 1641-7.

7. Jacobsen, Eva M et al. “Detection and quantification of lupus anticoagulants in plasma from heparin treated patients, using addition of polybrene.” Thrombosis journal vol. 4 3. 25 Jan. 2006, doi:10.1186/1477-9560-4-3

8. C. Boer, M.I. Meesters, D. Veerhoek, A.B.A. Vonk. "Anticoagulant and side-effects of protamine in cardiac surgery: a narrative review." British Journal of Anaesthesia Volume 120, Issue 5, May 2018, Pages 914-927

9. Kongkan, Chulalak, Kanitta Srinoun, Titirat Kaewmaneerat, & Tipparat Penglong. "The Effect of Polybrene on an aPTT-based Lupus Anticoagulant Test in the Plasma of Patients Receiving Unfractionated Heparin." Journal of Health Science and Medical Research [Online], 41.2 (2023): e2022913. Web.

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