Pexels - Polina Tankilevitch
A new chromogenic method for the in vitro quantitative determination of Factor FVIII activity is currently available as RUO with ARTG listing in progress.
This reagent measures the Factor VIII activity as does the BIOPHEN FVIII:C (#221402/ #221406) but is Emicizumab insensitive. It therefore allows measuring the inhibitory activity of anti-FVIII antibodies developed in haemophiliacs treated with Emicizumab and titrating their potency.
Episode 6, Tom talks about the problem of Heparin contamination in APTT testing. A previous study (link below) showed that heparin was responsible for 39% of unexpectedly prolonged APTT tests in patient samples where the patient was not taking heparin (or warfarin). Haematex offers HRRS/Antihepca for neutralizing heparin. It replaces the usual M/40 calcium chloride solution in APTT and KCT tests to virtually eliminate the effect of unfractionated heparin concentrations up to 1 u/ml in normal plasma. You can find Episode 6 of Tea with Tom, together with Tom’s other talks at: https://www.haematex.com/resources/twt
Link to study: https://doi.org/10.1093/ajcp/104.4.447
Last day for Hyphen orders - To ensure delivery before we close for the year, please email your orders to email@example.com before 5pm Monday 5th December 2022
Last dispatch date - Wednesday 21st December for overnight express TNT deliveries
Haematex Offices - will be closed from Friday 23rd Dec and re-open Monday 9th January.
Thank you for your ongoing support in purchasing Hyphen-BioMed and Haematex products.
As with most other businesses, we have experienced substantial increases to operating costs and from 1st January 2023, our quality supplier Hyphen-BioMed will be increasing their prices. Our price list for 2023 will reflect these changes. Please confirm prices with us at firstname.lastname@example.org before submitting your purchase order. Thanks for your understanding and we look forward to supplying you with you with high quality coagulation reagents in 2023.
Haematex is the only Australian distributor which carries out local R&D into coagulation diagnostics. When you purchase diagnostics from us, we allocate a portion of profits towards projects such as our own locally made DOAC-Stop™, Inhibitor Tubes, research on dRVVT and lupus anticoagulants.
All the team at Haematex would like to thank you for your continued support over 2022 and wish you all a safe and happy holiday season! Thanks for reading, we are grateful that we can act as your local coag news resource.
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Hyphen BioMed have released a new Liaphen test for Protein C. This joins the current Liaphen range, which are very simple one step quantitative tests for Fibrinogen, Antithrombin, free Protein S and von Willebrand factor.
WTD marks the birthdate of Professor Rudolph Virchow, founder of pathology and the "triad". Well not actually. It turns out that he contributed only 2 of the 3 key factors considered important for thrombosis to occur.
Doctor covid photo created by freepik - www.freepik.com
UPDATE ON DOAC STOP - A doctors’ “quip” online recently was “It usually requires a considerable time to determine with certainty the virtues of a new method of treatment and usually still longer to ascertain the harmful effects.” (Dr Alfred Blalock).
Photo by Polina Tankilevitch
UP IN THE CLOUDS - ISTH and ISLH VIRTUAL. What a pity not being able to go to beautiful Milano and surrounds. Anyway, Hyphen BioMed contributed a "workshop" at the virtual International Society on Thrombosis and Haemostasis meeting on selected recent developments.
Much excitement about the thrombotic complications emerging in Covid-19 disease. Heparin iv does not seem to be adequate in preventing this.
CDC - Microscopic shot of a Virus
Hope you all had an inspiring one on October 13. The online lecture by Jeff Weitz put out by the ISTH and emphasizing the significance of thrombosis among hospitalized patients was excellent, but I did not see much local publicity about this annual event.
We are very grateful to Dr Emmanuel Favaloro for including our DOAC neutralizing agent in a recent RCPA-QAP survey and publishing the results. "Neutralising rivaroxaban induced interference in laboratory testing for lupus anticoagulant (LA): A comparative study using DOAC-Stop™ and Andexanet alfa" is now available in Thrombosis Research.
Hyphen Biomed have just notified us of a new paper entitled: "Lysis Timer: a new sensitive tool to diagnose hyperfibrinolysis in liver transplantation" Roullet S, et al. J Clin Pathol 2018;0:1–8. doi:10.1136/jclinpath-2018-205280 The Lysis Timer is a device developed by Hyphen.
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Welcome to the final edition of the Haematex newsletter for 2017. We are very pleased to announce that Hyphen BioMed have added Edoxaban to their range of DOAC controls and calibrators. As with all their other DOAC plasmas, these are ARTG listed for use as IVDs and now available from Haematex.
Karolina Grabowska - Pexels.com
Let's start with ISTH 2017 Congress in Berlin, Germany where thousands of the world's leading experts on thrombosis & haemostasis came together to present the most recent advances and discuss the newest applications designed to improve patient care.
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Thank you to those brave enough to trial DOAC-Stop mini-tablets. We have been delighted with results coming in. External testing has confirmed that DOAC-Stop removes all Direct Oral Anti-Coagulants (DOACs; dabigatran, apixaban, rivaroxaban, and edoxaban, etc) from test plasmas with minimal effect on underlying blood clotting tests.
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The annoying problem of test plasmas unexpectedly containing heparin and affecting APTTs is easily resolved these days using Heparin Resistant Recalcifying Solution (HRRS). Our next pet project is removing the occasional DOAC from test plasmas needing additional clotting or chromogenic tests. DOACs affect practically every test in the coag lab.
ID 109894030 © creativecommonsstockphotos - Dreamstime.com
Lupus anticoagulant (LA) testing- people are doing it all over the place. The new kit on the block is the Hyphen HEMOCLOT LA-S (#CK090K) and corresponding LA-C (#CK091K). These are dilute Russell's Viper Venom Tests for the more specific detection of LA, the former being the screen and the latter is the confirm reagent.
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This group founded by Dr Jenny Curnow (Westmead Hospital) held an excellent meeting a few weeks ago in Sydney when Dr Claire McLintock (Auckland City Hospital) spoke about use of heparin in women with mechanical heart valves during pregnancy.
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