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The APTT is a widely accepted screening test for abnormalities in the intrinsic pathway of coagulation. It is also used for monitoring heparin, detecting inhibitors (including lupus anticoagulants) and for factor assays. A normal test result is dependent on the proper function of all the clotting factors and cofactors in the intrinsic and common pathways of the clotting mechanism. These include all known clotting factors except factor VII. Significantly decreased levels of any of these factors results in prolonged APTT results because the penultimate product thrombin, forms more slowly than usual. Agents which interfere with any part of this mechanism may also prolong an APTT. Thus the APTT test can be used to monitor anticoagulants such as heparin, to assess resistance to activated protein C and detect antibodies against clotting factors in mixing tests. It can also be used to detect lupus inhibitors which interfere with the low, rate-limiting level of phospholipid in the Intrinsin LS reagent. Intrinsin LR contains excess phospholipid and is therefore more resistant to these agents. Our APTT is a coherent, liquid stable product and when frozen can be repeatedly used without losing it’s activity. We guarantee a competitive price for our reagents.
Also available in bulk powders, please contact us for further information.
1. Proctor RR, Rapaport SI. The partial thromboplastin time with kaolin. A simple screening test for ﬁrst stage plasma clotting factor deﬁciencies. Am J Clin Pathol.1961; 35; 212.
2. CLSI. One-stage prothrombin time (PT) test and activated partial thromboplastin time (APTT) test; Approved guideline - Second edition. CLSI document H47-A2. Wayne, PA, USA: Clinical and Laboratory Standards Institute; 2008.
3. Brancaccio V, Ames PR, Glynn J, et al. A rapid screen for lupus anticoagulant with good discrimination from oral anticoagulants, congenital factor deﬁciency and heparin is provided by a comparing a sensitive and insensitive APTT reagent. Blood Coag. Fibrinolysis.1997; 8; 155-60.
4. Jacobsen EM, Barna-Cler L, Taylor JM, et al. The lupus ratio test - an interlaboratory study on the detection of Lupus Anticoagulants by an APTT-based, integrated and semi-quantitative test. Thromb. Haemost. 2000; 83; 704-8.
5. Smyth MA, Koerber JM, Westley SJ et al. Use of the activated partial thromboplastin time for heparin monitoring. Am J Clin Pathol. 2001;115; 148-155.
6. Pengo V, Tripodi A, Reber G, et al. Update of the guidelines for lupus anticoagulant detection. Thromb Haemost. 2009;7;1737-40.
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