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Sensitive test for Lupus Anticoagulant
Substitute for KCT or SCT
Surface Activated Clotting Time-II (SACT-II) reagent is a clear, stable, phospholipid-free suspension of an aluminosilicate mineral which activates contact factors similarly to kaolin or silica. The SACT-II reagent can thus be used as a substitute for kaolin suspension in kaolin clotting time (KCT) or silica clotting time tests as a screening test for LA, running in regular APTT mode on automated clotting instruments. Abnormal results need to be followed up mixing tests with normal plasma, use of HRRS (if heparin is suspected) and factor assays.
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8. Devreese K, Hoylaerts MF. Laboratory diagnosis of the antiphospholipid syndrome: a plethora of obstacles to overcome. European Journal of Haematology, 83: 1-16.
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