June 2025

Welcome to the Haematex Newsletter June 2025

FLY, FLY, FLY

FLYING TO ISTH WASHINGTON – JUNE 21-25?

We’d like to thank you for representing Australia and flying the flag for local research.

TSETSE FLY BREAKTHROUGH IN REVERSIBLE ANTICOAGULANTS  

A groundbreaking study by the University of Sydney and University of Geneva has introduced a new type of anticoagulant that can be switched on and off when needed—offering a safer, more controllable alternative to traditional blood thinners and current direct oral anticoagulants (DOACs). Development of supramolecular anticoagulants with on-demand reversibility.

Inspired by the blood-feeding tsetse fly, this innovative therapy uses supramolecular chemistry, where two peptides are connected by a reversible peptide nucleic acid (PNA) bond to block thrombin, the key enzyme in blood clotting. The effect can be simply reversed by adding a PNA antidote that breaks the link between the peptides, stopping the anticoagulant action instantly.

While anticoagulants are essential for preventing clots, managing the risk of bleeding has always been a challenge. Traditional drugs like heparin and warfarin require frequent monitoring and are associated with a high rate of bleeding-related hospital visits. Newer DOACs have helped address some issues, but their reversal agents are extremely expensive and not always ideal. Furthermore, DOACS cause interferences in laboratory coagulation testing, requiring neutralisation using DOAC-Stop™ to ensure accurate results. This next-generation supramolecular drug offers a unique combination of precision, reversibility, and safety, making it a promising advancement in coagulation therapy.

CONTROLS

Haematex offers a large range of third-party anticoagulant quality control (QC) materials to help your lab meet NATA accreditation requirements: Please see our full offering at https://www.haematex.com/products/hyphen-biomed-products

223501 BIOPHEN™ Orgaran® Control

223602 BIOPHEN™ NormalPlasma 2

223605 BIOPHEN™ NormalPlasma 5

224501 BIOPHEN™ Rivaroxaban Control Plasma

224701 BIOPHEN™ Dabigatran Control Plasma

225301 BIOPHEN™ Apixaban Control

225501 BIOPHEN™ Edoxaban Control

225701 BIOPHEN™ Bivalirudin Control

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We also offer a comprehensive range of testing solutions, including assays for thrombin inhibitors and anticoagulant testing, contact Melissa for more details melissa@haematex.com

Haematex is the only Australian distributor which carries out local R&D into coagulation diagnostics. When you purchase from us, a portion of profits go towards projects such as our own locally made DOAC-Stop™, and research on dRVVT and lupus anticoagulants. We hope this newsletter has been of interest, if you do not wish to receive future updates, please let us know.

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